Life-changing therapies

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• Polyphor Hosting Key Opinion Leader Roundtable on Covid-19: The Need for Novel Therapies for Severe Infections and the Potential Role of Balixafortide, a Selective CXCR4 Antagonist

• Polyphor's balixafortide demonstrates consistent dual action anti-viral and anti-inflammatory activity in COVID-19 preclinical trials

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Pipeline

Immuno-Oncology

Balixafortide (POL6326)
CXCR4 Inhibitor; metastatic breast cancer in combination with eribulin

Fast Track Designation granted by FDA

Phase III

Discovery

Preclinical

Phase I

Phase II

Phase III

Approval

Balixafortide (POL6326)
CXCR4 Inhibitor; other conditions/indications

Preclinical

Discovery

Preclinical

Phase I

Phase II

Phase III

Approval

Cystic Fibrosis / Respiratory

Inhaled Murepavadin – Pseudomonas infections in CF

Preclinical

Discovery

Preclinical

Phase I

Phase II

Phase III

Approval

Antibiotics

OMPTA platform –  targeting Gram-negative resistant pathogens

 

 

Preclinical

Discovery

Preclinical

Phase I

Phase II

Phase III

Approval

Thanatin Derivatives

 

Preclinical

Discovery

Preclinical

Phase I

Phase II

Phase III

Approval

Other

Cystic Fibrosis

POL6014 –Inhaled Elastase Inhibitor

Outlicensed to Santhera Pharmaceuticals 14.02.2018

Phase I

Discovery

Preclinical

Phase I

Phase II

Phase III

Approval

Macrocycle discovery platform

New modalities to address challenging biological targets

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