Scientific publications
D. Obrecht, F. Bernardini, G. Dale, K. Dembowsky, Annual Reports Med. Chem. 2011, 46, 245-262; Emerging New Therapeutics Against Key Gram-Negative Pathogens.
N. Srinivas, P. Jetter, B. J. Ueberbacher, M. Werneburg, K. Zerbe, J. Steinmann, B. Van der Meijden, F. Bernardini, A. Lederer, R. L. Dias, P. E. Misson, H. Henze, J. Zumbrunn, F. O. Gombert, D. Obrecht, P. Hunziker, S. Schauer, U. Ziegler, A. Käch, L. Eberl, K. Riedel, S. J. DeMarco, J. A. Robinson, Science 2010, 327, 1010-1013; Peptidomimetic Antibiotics Target Outer-Membrane Biogenesis in Pseudomonas aeruginosa.
D. Obrecht, J. A. Robinson, F. Bernardini, C. Bisang, S. J. DeMarco, K. Moehle, F. O. Gombert, Curr. Med. Chem. 2009, 16, 42-65; Recent Progress in the Discovery of Macrocyclic Compounds as Potential Anti-Infective Therapeutics.
J. A. Robinson, S. DeMarco, F. Gombert, K. Moehle, D. Obrecht, Drug Disc. Today 2008, 13, 944-951; The design, structures and therapeutic potential of protein epitope mimetics.
A. Ernst, D. Obrecht, Case Studies of ParallelSynthesis in Hit Identification, Hit Exploration, Hit-to-Lead, and Lead Optimization Programs, Chapter 3, p.99-115; in High-Throughput Lead Optimization in Drug Discovery; Ed. T.Kshirsagar, CRC Press, 2008.
A. Lederer, S. J. DeMarco; H. Henze, B. Romagnoli, R. Mukherjee, J. Zumbrunn, F. Brianza, F. O. Gombert, C. Ludin, J. W. Vrijbloed, J. –P. Obrecht, S. Lociuro,V. Brondani, F. Hamy, T. Klimkait, K. Moehle, J. A. Robinson, D., Chimia 2007, 61(4), 147-150. Discovery of highly potent and selective CXCR4 inhibitors using protein epitope mimetics (PEM) technology.
S. J. DeMarco, H. Henze, A. Lederer, K. Moehle, R. Mukherjee, B. Romagnoli, J. A. Robinson, F. Brianza, F. O. Gombert, S. Lociuro, Ch. Ludin, J.-W. Vrijbloed, J. Zumbrunn, J.-P. Obrecht, D. Obrecht, V. Brondani, F. Hamy, Th. Klimkait, Bioorg. Med. Chem. 2006, 14, 8396-8404. Discovery of novel, highly potent and selective ß-hairpin mimetic CXCR4 inhibitors with excellent anti-HIV activity and pharmacokinetic profiles.
R. Fasan, R. L. A. Dias, K. Moehle, O. Zerbe, D. Obrecht, P. E. Mittl, M. G. Grütter, J. A. Robinson, ChemBioChem 2006, 7, 515-26. Structure-Activity Studies in a Family of ß-Hairpin Protein Epitope Mimetic Inhibitors of the p53-HDM2 Protein-Protein Interaction.
R. L. Dias, R. Fasan, K. Moehle, A. Renard, D. Obrecht, J. A. Robinson, J. Am. Chem. Soc. 2006, 128, 2726-32; Protein Ligand Design: From Phage Display to Synthetic Protein Epitope Mimetics in Human Antibody Fc-Binding Peptidomimetics.
R. Fasan, R. L. A. Dias, K. Moehle, O. Zerbe, J. W. Vrijbloed, D. Obrecht, J. A. Robinson, Angew. Chem. 2004, 43, 2109-2112; Using a ß-hairpin to mimic an α-helix: Cyclic peptidomimetics of the p53-HDM2 protein-protein interaction.
M. Altorfer, P. Ermert, J. Fässler, S. Farooq, E. Hillesheim, A. Jeanguenat, K. Klumpp, P. Maienfisch, J. A. Martin, J. H. Merrett, K. E. B. Parkes, J. –P. Obrecht, T. Pitterna, D. Obrecht, Chimia 2003, 57, 262-269; Applications of Parallel Synthesis to Lead Optimization.
